Biphenyl → HCID 178474045、化合物

HRID 393659ノート

反応式

HRID 393659 の反応式
[C:1]([NH:4][C:5]1[N:10]=[C:9]([NH:11][CH:12]=[C:13]2[C:18](=[O:19])OC(C)(C)OC2=O)[CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C1(C2C=CC=CC=2)C=CC=CC=1.C1(OC2C=CC=CC=2)C=CC=CC=1>CCCCCC>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[C:9](=[N:11][CH:12]=[CH:13][C:18]=2[OH:19])[N:10]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 7095BiphenylHCID 7583Diphenyl EtherHCID 123544365-((6-Acetamido-2-pyridylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

生成物 1

HCID 178474045HCID 178474045、化合物収率 83%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

反応条件

温度
250 °C

実験手順

5-((6-Acetamido-2-pyridylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1.3 g, 4.3 mmol) was added in portions to a stirred mixture of biphenyl (13.3 ml) and phenyl ether (36.8 ml) heated at 250° C. and the resulting mixture was stirred for 1 hour at 250° C. The mixture was allowed to cool and was diluted with hexane. The precipitate was collected by filtration and dried to give 2-acetamido-5-hydroxy-1,8-naphthyridine (720 mg, 83%).

後処理

  1. temperatureto cool
  2. filtrationThe precipitate was collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-2e24f521cd0f4d6ca51b85ee33644e16
出典データセット
uspto-grants-2004_10
特許番号
US06809097B1

反応ノート

読み込み中…