Hydrochloric Acid → 2-Amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine

HRID 393661ノート

反応式

HRID 393661 の反応式
Cl.C([NH:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[NH:16][C:17]2[CH:22]=[C:21]([OH:23])[C:20]([CH3:24])=[CH:19][C:18]=2[F:25])[N:7]=1)(=O)C.Cl>C(O)C>[NH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[NH:16][C:17]2[CH:22]=[C:21]([OH:23])[C:20]([CH3:24])=[CH:19][C:18]=2[F:25])[N:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 226465602-Acetamido-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine hydrochloride

生成物 1

HCID 223464762-Amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine収率 76.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-acetamido-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine hydrochloride (170 mg, 0.46 mmol), (prepared as described in Example 53), and concentrated hydrochloric acid (0.5 ml) in ethanol (10 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the organic volatiles were removed by evaporation. The aqueous residue was basified to pH9 with aqueous sodium hydroxide solution and the resulting precipitate was collected by filtration, washed with water and dried to give 2-amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine (100 mgs 76%).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. temperatureto cool
  4. customthe organic volatiles were removed by evaporation
  5. filtrationthe resulting precipitate was collected by filtration
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-3dfb93076314459db3a7ce4325c3b611
出典データセット
uspto-grants-2004_10
特許番号
US06809097B1

反応ノート

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