5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 5-(3,4-Dichlorophenyl)-2-piperazin-1-yl-pyrimidine, dihydrochloride

HRID 393728ノート

反応式

HRID 393728 の反応式
[ClH:1].Cl.FC1C=CC(C2C=NC(N3CCNCC3)=NC=2)=CC=1.C(OC([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[N:40]=[CH:39][C:38]([C:41]3[CH:46]=[CH:45][C:44]([Cl:47])=[C:43]([Cl:48])[CH:42]=3)=[CH:37][N:36]=2)[CH2:31][CH2:30]1)=O)(C)(C)C>>[ClH:47].[ClH:1].[Cl:48][C:43]1[CH:42]=[C:41]([C:38]2[CH:37]=[N:36][C:35]([N:32]3[CH2:31][CH2:30][NH:29][CH2:34][CH2:33]3)=[N:40][CH:39]=2)[CH:46]=[CH:45][C:44]=1[Cl:47]

参加物

3

反応物 2

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 698949894-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 1317245825-(3,4-Dichlorophenyl)-2-piperazin-1-yl-pyrimidine, dihydrochloride収率 90%

実験手順

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (0.93 g), to furnish the title compound as an off-white solid (0.78 g, 90%).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-bccee48f997e420ca74532769db11ad7
出典データセット
uspto-grants-2004_10
特許番号
US06809100B2

反応ノート

読み込み中…