Methyl heptanoate → Lithium heptanoate

HRID 3939

反応式

HRID 3939 の反応式
[C:1]([O:9]C)(=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C[Si](C)(C)[O-].[Li+:16]>C1(C)C=CC=CC=1>[C:1]([O-:9])(=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[Li+:16]

参加物

4

反応物 2

HCID 7826Methyl heptanoateHCID 74821Lithium trimethylsilanolate

生成物 1

HCID 23665556Lithium heptanoate収率 51.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The procedure of Example 1 was followed using methyl heptanoate (5 mL, 30.2 mmol), lithium trimethylsilanolate (2.90 g, 30.2 mmol), dry toluene (50 mL) and 2.5 h of heating at reflux. Lithium heptanoate (2.1 g, 51% yield) was isolated as a white solid: 1H NMR (D2O) δ 0.7 (t, J=5.3 Hz, CH3, 3H), 0.9-1.7 (m, CH2, 8H), 2.1 ppm (t, --CH2CO2-Li+, J=7.2 Hz, 2H). Anal. Calcd. for C7H13LiO2 : C, 61.77; H, 9.63; Li, 5.10. Found: C, 59.84, 59.89; H, 9.47, 9.47; Li, 5.01.

後処理

  1. temperatureof heating
  2. temperatureat reflux

出典と根拠

ORDレコード
ord-3800576022a3461eb93d34d2f8d0dcb9
出典データセット
uspto-grants-1988_02
特許番号
US04723016

関連ノート

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