2-Methyl-1-phenylpropan-2-yl 6-bromo-5-hydroxy-3-oxohexanoate → HCID 67608343、化合物

HRID 39399

反応式

HRID 39399 の反応式
[Br:1][CH2:2][CH:3]([OH:21])[CH2:4][C:5](=[O:20])[CH2:6][C:7]([O:9][C:10]([CH3:19])([CH3:18])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:8].ClCC(O)CC(=O)CC(OC(C)(C)CC1C=CC=CC=1)=O>>[Br:1][CH2:2][C@@H:3]([OH:21])[CH2:4][C@@H:5]([OH:20])[CH2:6][C:7]([O:9][C:10]([CH3:18])([CH3:19])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:8]

参加物

3

反応物 2

HCID 676083512-Methyl-1-phenylpropan-2-yl 6-bromo-5-hydroxy-3-oxohexanoateHCID 676083592-Methyl-1-phenylpropan-2-yl 6-chloro-5-hydroxy-3-oxohexanoate

生成物 1

HCID 67608343HCID 67608343、化合物

実験手順

The procedure was carried out in the same manner as in Example 3, except that the crude compound (2-methyl-1-phenylpropan-2-yl 6-bromo-5-hydroxy-3-oxohexanoate (7b, 80.0 g) prepared in Example 2 was used in place of (2-methyl-1-phenylpropan-2-yl 6-chloro-5-hydroxy-3-oxohexanoate (7a, 80.0 g). The crude title compound was obtained (12.0 g). A portion of the crude compound was purified by silica gel column (ethyl acetate:n-hexane=3:7(v/v)) to obtain the following NMR data.

後処理

  1. customprepared in Example 2

出典と根拠

ORDレコード
ord-d342648e27f1403db8799678b015d79b
出典データセット
uspto-grants-2013_09
特許番号
US08524914B2

関連ノート

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