(2-Methoxy-5-methylphenyl)(phenyl)methanone → 4-Hydroxy-3-(1-phenyl-vinyl)-benzoic acid methylester

HRID 394000

反応式

HRID 394000 の反応式
COC1C=CC(C)=CC=1C(C1C=CC=CC=1)=O.[CH2:18]([O:20][C:21](=[O:44])[C:22]1[CH:27]=[CH:26][C:25]([O:28]CC2C=CC=CC=2)=[C:24]([C:36]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[CH2:37])[CH:23]=1)C>>[CH3:18][O:20][C:21](=[O:44])[C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([C:36]([C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)=[CH2:37])[CH:23]=1

参加物

3

反応物 2

HCID 249273(2-Methoxy-5-methylphenyl)(phenyl)methanoneHCID 235330294-Benzyloxy-3-(1-phenyl-vinyl)-benzoic acid ethylester4 回

生成物 1

HCID 226484304-Hydroxy-3-(1-phenyl-vinyl)-benzoic acid methylester

実験手順

1H-NMR (400 MHz, CDCl3): δ [ppm]=3.84 (s, 3H, CH3), 5.42 (d, 2J=1.0 Hz, 1H, ═CH2), 5.88 (d, 2J=1.0 Hz, 1H, ═CH2), 6.97 (d, 3J=8.5 Hz, 1H, PhH), 7.32 (m, 5H, PhH), 7.88 (d, 4J=2.3 Hz, 1H, PhH), 7.94 (dd, 3J=8.5 Hz, 4J=2.3 Hz, 1H, PhH). 13C-NMR (100 MHz, CDCl3): δ [ppm]=51.9 (CH3), 115.8 (CHarom), 117.4 (═CH2), 122.4 (Cqarom), 126.8 (2×CHarom), 127.6 (Cqarom), 128.7 (CHarom), 128.7 (2×CHarom), 131.3 (CHarom), 132.4 (CHarom), 138.8 (Cqarom), 144.3 (Cqolefin), 157.3 (Cqarom), 166.8 (COOMe). MS (EI, 70EV): m/z [%]=254 (M+, 5), 253 (7), 239 (3), 223 (1), 165 (1), 152 (1), 131 (1), 120 (22), 105 (44), 91 (100), 77 (37), 65 (13), 59 (16), 51 (20), 45 (17).

出典と根拠

ORDレコード
ord-3e3520697a3946e3a20f779332e656ca
出典データセット
uspto-grants-2004_10
特許番号
US06809225B2

関連ノート

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