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1-(1,1-dimethylethyl)-N-(phenylmethyl)-4-Piperidinamine → 1-tert-Butylpiperidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(1,1-dimethylethyl)-N-(phenylmethyl)-4-Piperidinamine | HCID 22647939 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-tert-Butylpiperidin-4-amine | HCID 17750401 | — |
反応手順
A solution of N-benzyl-1-tert-butylpiperidin-4-amine (150 mg) and 10% palladium on carbon (200 mg) in 30 mL of MeOH was hydrogenated in a Parr shaker at 50 psi for 16 h. The solution was filtered and concentrated to give 1-tert-butylpiperidin-4-amine which was used without further purification. Mass spectrum (ESI) 157 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809199B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-3bbf075918b34a16b45586336ac27820 |
| 出典メモ | uspto-grants-2004_10 |