Tert-butyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl]amino}piperidine-1-carboxylate → 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-1,6-naphthyridin-2(1h)-one
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:17]=[C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]2)[CH:15]=[C:14]2[C:9]=1[CH:10]=[CH:11][C:12](=[O:40])[N:13]2[C:32]1[C:37]([Cl:38])=[CH:36][CH:35]=[CH:34][C:33]=1[Cl:39].ClC1C=CC=CC=1C1N=C(NC2CCN(C(C)C)CC2)C=C2C=1C=CC(=O)N2C1C(Cl)=CC=CC=1Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:17]=[C:16]([NH:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[CH:15]=[C:14]2[C:9]=1[CH:10]=[CH:11][C:12](=[O:40])[N:13]2[C:32]1[C:33]([Cl:39])=[CH:34][CH:35]=[CH:36][C:37]=1[Cl:38]参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared from tert-butyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl]amino}piperidine-1-carboxylate by a procedure analogous to that described in EXAMPLE HHH2, Step C. Mass spectrum (ESI) 501 (M+1). Step C: 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(1-isopropylpiperidin-4-yl)amino]-1,6-naphthyridin-2(1H)-one