Morpholine → N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]-3-morpholin-4-ylpropane-1-sulfonamide

HRID 394199ノート

反応式

HRID 394199 の反応式
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][N:14]([CH2:28][C:29]3[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=3)[C:15](=[O:27])[N:16]2[C:19]2[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:26])=[C:11]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[Cl:43])[CH:10]=1)(=[O:7])=[O:6].[NH:44]1[CH2:49][CH2:48][O:47][CH2:46][CH2:45]1>C(OCC)(=O)C>[Cl:43][C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=1[C:11]1[CH:10]=[C:9]([NH:8][S:5]([CH2:4][CH2:3][CH2:2][N:44]2[CH2:49][CH2:48][O:47][CH2:46][CH2:45]2)(=[O:6])=[O:7])[CH:18]=[C:17]2[C:12]=1[CH2:13][N:14]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)[C:15](=[O:27])[N:16]2[C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:26]

参加物

4

反応物 2

HCID 8083MorpholineHCID 22647935HCID 22647935、化合物

生成物 1

HCID 22648174N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]-3-morpholin-4-ylpropane-1-sulfonamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3chloro-N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]propane-1-sulfonamide (93 mg, 0.14 mmol) in morpholine (0.25 mL) was heated at 130° C. for 45 min. The reaction mixture was cooled to rt, diluted with ethyl acetate, washed with water, dried (Na2SO4), and concentrated under reduced pressure. The product was purified by flash chromatography on a Biotage 40S column, eluting with 60:40 hexanes-acetone to yield N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]-3-morpholin-4-ylpropane-1-sulfonamide. Mass spectrum (ESI) 729 (M+1).

後処理

  1. washwashed with water
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated under reduced pressure
  4. customThe product was purified by flash chromatography on a Biotage 40S column
  5. washeluting with 60:40 hexanes-acetone

出典と根拠

ORDレコード
ord-6d732f5085a642e686ea0141c7061109
出典データセット
uspto-grants-2004_10
特許番号
US06809199B2

反応ノート

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