Hydrochloric Acid → 4-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride

HRID 39422

反応式

HRID 39422 の反応式
C(OC(=O)[NH:7][C@H:8]1[C@H:13]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([CH:13]2[CH2:12][CH2:11][O:10][CH2:9][CH:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67358972HCID 67358972、化合物2 回

生成物 1

HCID 673600044-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

trans-(4-Pyrrolidin-1-yl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (intermediate H, 345 mg, 1.28 mmol) was dissolved in 6.4 mL dioxane. Hydrochloric acid (4N in dioxan, 3.2 mL, 13 mmol) was added. The reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated off. The crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification.

後処理

  1. customThe solvent was evaporated off
  2. customThe crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification

出典と根拠

ORDレコード
ord-fea28dbce15a4b2aa7955dfd9fe63643
出典データセット
uspto-grants-2013_09
特許番号
US08524909B2

関連ノート

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