化工社化工社 化学情報印刷レポート · 研究参考用
1,3-Dichloroacetone → [Rac]-2-ethoxy-3-{4-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethoxy]-3-methyl-phenyl}-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dichloroacetone | HCID 10793 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-(Propan-2-yl)benzene-1-carbothioamide | HCID 2078831 | — |
| 反応物 | 4-Chloromethyl-2-(4-isopropyl-phenyl)-thiazole | HCID 2095697 | — |
| 反応物 | Ethyl 2-ethoxy-3-(4-hydroxy-3-methylphenyl)propanoate | HCID 22708451 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | [Rac]-2-ethoxy-3-{4-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethoxy]-3-methyl-phenyl}-propionic acid ethyl ester | HCID 68617181 | — |
反応手順
In analogy to the procedure described in example 4 d], [rac]-2-ethoxy-3-(4-hydroxy-3-methyl-phenyl)-propionic acid ethyl ester (example 4 c]) was reacted with 4-chloromethyl-2-(4-isopropyl-phenyl)-thiazole (prepared from 4-isopropyl-thiobenzamide and 1,3-dichloroacetone in analogy to the procedure described in example 4 a]) in acetonitrile in the presence of cesium carbonate to yield [rac]-2-ethoxy-3-{4-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethoxy]-3-methyl-phenyl}-propionic acid ethyl ester, which was further saponified in analogy to the procedure described in example 4 e], to yield [rac]-2-ethoxy-3-{4-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethoxy]-3-methyl-phenyl}-propionic acid as colorless gum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809110B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-9dd52754fb0f4d4aa8243b639a3606fa |
| 出典メモ | uspto-grants-2004_10 |