化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Iodide → [Rac]-3-{4-[2-(2-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | 1,3-Dichloroacetone | HCID 10793 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-(Chloromethyl)-2-(2-chlorophenyl)-1,3-thiazole | HCID 2063595 | — |
| 反応物 | 2-Chlorothiobenzamide | HCID 2734824 | — |
| 反応物 | [Rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester | HCID 57792490 | — |
| 生成物 | [Rac]-3-{4-[2-(2-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester | HCID 68616604 | — |
反応手順
In analogy to the procedure described in example 14 b], [rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester (example 10 b]) was reacted with 4-chloromethyl-2-(2-chloro-phenyl)-thiazole (prepared from 2-chloro-thiobenzamide and 1,3-dichloroacetone in analogy to the procedure described in example 4 a]) in the presence of cesium carbonate and potassium iodide to yield [rac]-3-{4-[2-(2-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester as colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809110B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-9ae37796bb294f0d88f13f71bb5de6dc |
| 出典メモ | uspto-grants-2004_10 |