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Methyl heptanoate → 2-[(4-Benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl heptanoate | HCID 7826 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 反応物 | 2-Methyl 4-benzyloxybenzaldehyde | HCID 2759806 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-[(4-Benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester | HCID 68616679 | — |
反応手順
In analogy to the procedure described in example 125 a], methyl heptanoate was deprotonated with lithium diisopropylamide and reacted with 4-benzyloxy-2-methyl-benzaldehyde in tetrahydrofuran to obtain 2-[(4-benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester as a mixture of two diastereomeric racemates as light yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809110B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-c3eee6e3a1914b60be869ec077ced694 |
| 出典メモ | uspto-grants-2004_10 |