Bromopinacolone → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 394429

反応式

HRID 394429 の反応式
[Br:1][CH2:2][C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5].O[C:10]1[S:14][C:13](O)=[C:12](O)[C:11]=1O>CC(C)=O>[Br-:1].[O:8]=[C:3]([C:4]([CH3:7])([CH3:6])[CH3:5])[CH2:2][S+:14]1[CH2:10][CH2:11][CH2:12][CH2:13]1

参加物

4

反応物 2

HCID 21642BromopinacoloneHCID 18175936Tetrahydroxythiophene

生成物 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide収率 142.7%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

In a 300 ml three-necked flask, 2 g of tetrahydroxythiophene was dissolved in 20 ml of acetone. To the solution, 4.87 g of 1-bromo-3,3-dimethy 2-butanone was added dropwise while stirring. After leaving for 24 hours, the deposited white crystal was collected by filtration. The white crystal was ground to a powder, which was washed with ether. The powder was dried by a vacuum drier at 30° C. for six hours to obtain 5.15 g of 2-oxo-3,3-dimethylbutyl-thiacyclopentanium bromide (yield: 75.0%).

後処理

  1. customAfter leaving for 24 hours
  2. filtrationthe deposited white crystal was collected by filtration
  3. washwas washed with ether
  4. customThe powder was dried by a vacuum drier at 30° C. for six hours

出典と根拠

ORDレコード
ord-281edd52038f459f88555e5efe0d8eb4
出典データセット
uspto-grants-2003_08
特許番号
US06602647B2

関連ノート

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