化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → N-Acetyl-7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 2-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride | HCID 12606904 | — |
| 反応物 | 7-(Morpholine-4-sulfonyl)-1,2,3,4-tetrahydroisoquinoline | HCID 21983663 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-Acetyl-7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | HCID 18176496 | — |
反応手順
was obtained as described in Example 4A by reacting morpholine with 2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride in the presence of diisopropylamine in THF and by heating with 50% concentrated hydrochloric acid and, after alkaline workup, converted into the corresponding 7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06602867B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-4465e0f4aed34412858468b27119c327 |
| 出典メモ | uspto-grants-2003_08 |