2-chloro-N,N-dimethyl-3-nitro-aniline → 2-Chloro-3-dimethylaminoaniline

HRID 394578ノート

反応式

HRID 394578 の反応式
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[C:4]=1[Cl:12].[H][H]>CO.[Ni]>[Cl:12][C:4]1[C:3]([N:2]([CH3:13])[CH3:1])=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:9]

参加物

5

反応物 2

HCID 227123482-chloro-N,N-dimethyl-3-nitro-anilineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 227123462-Chloro-3-dimethylaminoaniline収率 49.5%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

30.4 g of N,N-dimethyl-2-chloro-3-nitroaniline is dissolved in about 300 ml of MeOH and hydrogenated at 20° C. and 5 bars pressure of hydrogen using Raney nickel as catalyst. The solvent is evaporated down and the product is purified by chromatography (silica gel, eluant: petroleum ether/ethyl acetate (3/1)). 12.8 g of 2-chloro-3-dimethylaminoaniline is obtained as a brown oil.

後処理

  1. customThe solvent is evaporated down
  2. customthe product is purified by chromatography (silica gel, eluant: petroleum ether/ethyl acetate (3/1))

出典と根拠

ORDレコード
ord-5bd183b5c80e4da6ac9edaadda7ea8b9
出典データセット
uspto-grants-2003_08
特許番号
US06602897B2

反応ノート

読み込み中…