Acrylonitrile → 3-(4-Methoxyphenoxy)propanenitrile

関与物質

反応手順

A mixture of 4-methoxyphenol (10 g: 80.5 mmol) and Triton B (2.29 ml:14.5 mmol:0.18 eq.) in acrylonitrile (50 ml) is heated at reflux for 48 hours. After the solvent has been partially removed, the products are extracted with ethyl acetate and washed with water and then with a 6N hydrochloric acid solution. The residual chestnut-brown oil is purified on a flash silica column eluted with an AcOEt/PE gradient.

情報源と証拠