Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoate → Phthalimidoamlodipine

HRID 394821

反応式

HRID 394821 の反応式
[NH2:1]/[C:2](/[CH2:9][O:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=[CH:3]\[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Cl:24][C:25]1[CH:39]=[CH:38][CH:37]=[CH:36][C:26]=1[CH:27]=[C:28]([C:33]([CH3:35])=O)[C:29]([O:31][CH3:32])=[O:30]>C(O)C>[Cl:24][C:25]1[CH:39]=[CH:38][CH:37]=[CH:36][C:26]=1[CH:27]1[C:28]([C:29]([O:31][CH3:32])=[O:30])=[C:33]([CH3:35])[NH:1][C:2]([CH2:9][O:10][CH2:11][CH2:12][N:13]2[C:14](=[O:23])[C:15]3=[CH:22][CH:21]=[CH:20][CH:19]=[C:16]3[C:17]2=[O:18])=[C:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

参加物

4

反応物 2

HCID 299600Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoateHCID 11174576HCID 11174576、化合物

生成物 1

HCID 9871958Phthalimidoamlodipine収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

24.0 g (75.4 mmoles) of ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and 18.9 g (79.2 mmoles) of methyl 2-(2-chlorobenzylidene)acetoacetate in 64 ml of ethanol were heated under reflux for 20 hours. The reaction mixture was diluted with 56 ml of ethanol and was cooled to crystallise the product. 14.2 g (yield 70%) of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(2-phthalimidoethoxy)methyl-1,4-dihydropyridine were obtained.

後処理

  1. temperatureunder reflux for 20 hours
  2. temperaturewas cooled
  3. customto crystallise the product

出典と根拠

ORDレコード
ord-3435c4404c6640cf91f4a87b281daaab
出典データセット
uspto-grants-2003_08
特許番号
US06603006B2

関連ノート

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