Acetic Acid → Pantoprazole

関与物質

反応条件

反応手順

310 mg of 5-difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazol were dissolved in 1.5 ml of methanol and 12 mg of ammonium molybdate added. The solution was cooled to 51C and 0.11 g of sodium percarbonate were added, then kept stirred at the same temperature for 4 h. After the reaction ended 3 ml of water were added, then heating to 20° C. and adjusting the mixture of the pH to 7.5 with acetic acid. The mixture is extracted with 5 ml of dichloromethane and the organic phase separated, then washed with 10 ml of water. The solvent was evaporated at a reduced pressure. 274 mg of pantoprazol were obtained (yield: 88%).

情報源と証拠