Iodine → 2-(4-Bromo-2-chlorophenyl)-1,3-oxazole
反応式
[Br:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][CH2:9][CH:10]=[O:11])=O)=[C:4]([Cl:14])[CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.II.C(N(CC)CC)C>C(Cl)Cl>[Br:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]2[O:11][CH:10]=[CH:9][N:8]=2)=[C:4]([Cl:14])[CH:3]=1参加物
6
実験手順
To a stirred solution of 4-bromo-2-chloro-N-(2-oxoethyl)benzamide (1.00 g, 3.617 mmol) in CH2Cl2 (30 mL) were added triphenylphosphine (1.90 g, 7.234 mmol), iodine (1.84 g, 7.234 mmol) and triethylamine (2.0 mL, 14.47 mmol) at room temperature. After 24 hour, the mixture was washed with water (20 mL), dried over MgSO4. Removal of the solvent, gave an oily recidue, which was purified by flash chromatography eluting with ethyl acetate/hexane (1/5) to give title compound (0.185 g, 20% yield).
後処理
- washthe mixture was washed with water (20 mL)
- dry with materialdried over MgSO4
- customRemoval of the solvent
- customgave an oily recidue, which
- customwas purified by flash chromatography
- washeluting with ethyl acetate/hexane (1/5)
出典と根拠
- ORDレコード
- ord-28f5235f7fd94425bacb3390a13fa483
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06603008B1
反応ノート
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