5-{4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide → 5-[5-[4-(1,3-Thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide Hydrochloride
反応式
[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]([C:17]4[CH:18]=[CH:19][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[N:21][CH:22]=4)[N:15]=[C:14]([C:27]([F:30])([F:29])[F:28])[CH:13]=3)=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1.[Cl:31]C1C(C(F)(F)F)=NN(C2C=CC(S(N)(=O)=O)=NC=2)C=1C1C=CC(C2N=CSC=2)=CC=1>>[ClH:31].[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]([C:17]4[CH:18]=[CH:19][C:20]([S:23]([NH2:26])(=[O:24])=[O:25])=[N:21][CH:22]=4)[N:15]=[C:14]([C:27]([F:28])([F:29])[F:30])[CH:13]=3)=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared according to the procedure of Example 4 using 5-[5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide, instead of 5-{4-chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide.