Bromine → 2-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone

HRID 394883

反応式

HRID 394883 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([CH3:11])[CH:3]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][C:4]=1[CH3:11])=[O:10]

参加物

4

反応物 2

HCID 24408BromineHCID 701334-Hydroxy-2-methylacetophenone

生成物 1

HCID 178121702-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone収率 81%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a stirred solution of 4′-hydroxy-2′-methylacetophenone (4.5 g, 30.0 mmol) in dioxane (7 ml) was added a solution of bromine (4.87 g, 30.5 mmol) in dioxane (28 ml) dropwise at room temperature. After addition, the mixture was stirred at room temperature for 30 minutes. The volatile was evaporated in vacuo, and the residue was used for next reaction without further purification. (5.57 g, 81% yield).

後処理

  1. additionAfter addition
  2. customThe volatile was evaporated in vacuo
  3. customthe residue was used for next reaction without further purification

出典と根拠

ORDレコード
ord-c9930b85b2304d91879edd2c1c740489
出典データセット
uspto-grants-2003_08
特許番号
US06603008B1

関連ノート

読み込み中…