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3-Iodophthalic anhydride → 3-Iodo-N-(1-methyl-3-methylthiopropyl)-phthalamic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Iodophthalic anhydride | HCID 282071 | — |
| 反応物 | 4-(Methylsulfanyl)butan-2-amine | HCID 22979404 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-Iodo-N-(1-methyl-3-methylthiopropyl)-phthalamic Acid | HCID 18178020 | 89.2% |
反応手順
To a suspension of 2.74 g of 3-iodophthalic anhydride in 8 ml of acetonitrile cooled with ice was slowly added dropwise a solution of 1.19 g of 1-methyl-3-methylthiopropylamine in 3 ml of acetonitrile. After completion of the dropping, a reaction was carried out at room temperature for 3 hours with stirring. After completion of the reaction, the deposited crystal was collected by filtration and washed with a small quantity of acetonitrile. Thus, 3.5 g of the objective compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06603044B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-44769b3aa80b4d76933f15c5015bfff4 |
| 出典メモ | uspto-grants-2003_08 |