2,5-Dimethoxybenzaldehyde → 2,5-Dimethoxy-4'-prop-2-enyloxychalcone

HRID 394969ノート

反応式

HRID 394969 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH:12]=[CH2:13])=[CH:6][CH:5]=1)=[O:3].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:17]=1[CH:18]=O>>[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:17]=1[CH:18]=[CH:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH:12]=[CH2:13])=[CH:6][CH:5]=1)=[O:3]

参加物

3

反応物 2

HCID 667262,5-DimethoxybenzaldehydeHCID 959691-(4-(2-Propen-1-yloxy)phenyl)ethanone

生成物 1

HCID 541484062,5-Dimethoxy-4'-prop-2-enyloxychalcone収率 83%

実験手順

1.76 g (10 mmol) of 4-allyloxyacetophenone and 1.66 g (10 mmol) of 2,5-dimethoxy-benzaldehyde were under an inert atmosphere (argon) dissolved in 10 ml of dry freshly distilled ethanol, and 100 mg of sodium hydroxide was added to the solution. The mixture was left under stirring for 2.5 h and filtered. The precipitate was recrystallized from methanol to give 2.50 g (83%) of 2,5-dimethoxy-4′-prop-2-enyloxychalcone, m.p. 86-87° C.

後処理

  1. dissolutiondissolved in 10 ml
  2. dry with materialof dry freshly distilled ethanol, and 100 mg of sodium hydroxide
  3. additionwas added to the solution
  4. waitThe mixture was left
  5. filtrationfiltered
  6. customThe precipitate was recrystallized from methanol

出典と根拠

ORDレコード
ord-c1cd1a4b4781411cbfa4335d7cded9f1
出典データセット
uspto-grants-2003_08
特許番号
US06603046B1

反応ノート

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