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2,3-Dihydrofuran → Methyl 2-(Difluoromethyl)-4-(2-methylpropyl)-5-[(tetrahydro-2-furyl)thio]-6-(trifluoromethyl)-3-pyridinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Dihydrofuran | HCID 70934 | — |
| 反応物 | Methyl 2-(difluoromethyl)-4-isobutyl-5-mercapto-6-(trifluoromethyl)-3-pyridinecarboxylate | HCID 9974711 | — |
| 触媒 | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Methyl 2-(Difluoromethyl)-4-(2-methylpropyl)-5-[(tetrahydro-2-furyl)thio]-6-(trifluoromethyl)-3-pyridinecarboxylate | HCID 22668859 | 68% |
反応手順
A mixture of 7.07 g (0.021 mol) of compound 7, 2.92 g (0.042 mol) of dihydrofuran, and catalytic toluenesulfonic acid (9 mg) in 80 ml of ether was stirred overnight. The reaction mixture was concentrated in vacuo, and the residue was purified by HPLC (20% EtOAc in hexane) to give 5.82 g (68%) of the desired product as a yellow oil, n25D 1.5803.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06605624B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-a9da341029bb48f9be78671f29ee9d6a |
| 出典メモ | uspto-grants-2003_08 |