2-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride → Methyl 5-{[2-Chloro-4-(trifluoromethyl)-5-thiazolyl]carbonylamino}-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

HRID 395412ノート

反応式

HRID 395412 の反応式
[NH2:1][C:2]1[C:3]([CH2:19][CH:20]([CH3:22])[CH3:21])=[C:4]([C:15]([O:17][CH3:18])=[O:16])[C:5]([CH:12]([F:14])[F:13])=[N:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[Cl:23][C:24]1[S:25][C:26]([C:33](Cl)=[O:34])=[C:27]([C:29]([F:32])([F:31])[F:30])[N:28]=1>>[Cl:23][C:24]1[S:25][C:26]([C:33]([NH:1][C:2]2[C:3]([CH2:19][CH:20]([CH3:22])[CH3:21])=[C:4]([C:15]([O:17][CH3:18])=[O:16])[C:5]([CH:12]([F:14])[F:13])=[N:6][C:7]=2[C:8]([F:10])([F:11])[F:9])=[O:34])=[C:27]([C:29]([F:30])([F:31])[F:32])[N:28]=1

参加物

3

反応物 2

HCID 132827442-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chlorideHCID 15676771Methyl 5-amino-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

生成物 1

HCID 18174413Methyl 5-{[2-Chloro-4-(trifluoromethyl)-5-thiazolyl]carbonylamino}-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

実験手順

Methyl 5-amino-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate (example A1 of U.S. Pat. No. 5,114,465) was reacted with 2-chloro-4-(trifluoromethyl)-5-thiazolecarbonyl chloride according to the procedure in example 1 of U.S. Pat. No. 5,114,465 afforded the product.

後処理

  1. custom5,114,465 afforded the product

出典と根拠

ORDレコード
ord-e34932e41b514e44b3e2c7f21ef1420b
出典データセット
uspto-grants-2003_08
特許番号
US06605624B1

反応ノート

読み込み中…