Ethyl 2-chloroisonicotinate → Ethyl 2-(4-chloro-3,5-dimethoxyphenyl)isonicotinate

反応式

[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5](B(O)O)=[CH:4][C:3]=1[O:13][CH3:14].Cl[C:16]1[CH:17]=[C:18]([CH:24]=[CH:25][N:26]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:16]2[CH:17]=[C:18]([CH:24]=[CH:25][N:26]=2)[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:4][C:3]=1[O:13][CH3:14]

参加物

反応物 2

HCID 2762942Ethyl 2-chloroisonicotinate

HCID 22485557(4-Chloro-3,5-dimethoxyphenyl)boronic acid

生成物 1

HCID 22557799Ethyl 2-(4-chloro-3,5-dimethoxyphenyl)isonicotinate

実験手順

4-Chloro-3,5-dimethoxyphenylboronic acid (7.45 g) and ethyl 2-chloroisonicotinate (6.39 g) were condensedn in the same manner as described in Preparation Example 1 to give the title compound.

後処理

customas described in Preparation Example 1

出典と根拠

ORDレコード: ord-df9a1b14f15a4ddeaca9487ad6b9af68
出典データセット: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06605620B1

反応ノート

読み込み中…