4-Amino-1-butanol → 3-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide
反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[OH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][OH:19])=[O:14]参加物
3
実験手順
3-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.5 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.63 mmol of 4-hydroxy-butylamine. LC/MS [8.42 min; 430 (M+1)]
後処理
- customLC/MS [8.42 min; 430 (M+1)]
出典と根拠
- ORDレコード
- ord-5e112f12989c4339bf648c0c9e6f01d3
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524911B2
反応ノート
読み込み中…