Trifluoroacetic acid methylene chloride → 2-Chloro-N-[(2R)-2,3-dihydroxy-propoxy]-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide
反応式
[Cl:1][C:2]1[C:3]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[F:28])=[C:4]([CH:17]=[CH:18][N:19]=1)[C:5]([NH:7][O:8][CH2:9][C@H:10]1[CH2:14][O:13]C(C)(C)[O:11]1)=[O:6].C(O)(C(F)(F)F)=O.ClCCl>>[Cl:1][C:2]1[C:3]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[F:28])=[C:4]([CH:17]=[CH:18][N:19]=1)[C:5]([NH:7][O:8][CH2:9][C@H:10]([OH:11])[CH2:14][OH:13])=[O:6]参加物
3
実験手順
Deprotection of 2-Chloro-N-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide with 50:50 mixture of TFA/dichloromethane at room temperature for 30 minutes afforded the desired product. Purification by reverse phase LC/MS [7.94 min; 482 (M+1)].
出典と根拠
- ORDレコード
- ord-22f9770fa0e645b098c8c8c7298e0434
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524911B2
反応ノート
読み込み中…