4-(Trifluoromethyl)aniline → 1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

HRID 395537ノート

反応式

HRID 395537 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]([F:25])([F:24])[C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:21][C:20]2[CH:22]=[CH:23][C:17]([C:16]([F:15])([F:24])[F:25])=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 99644-(Trifluoromethyl)anilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

生成物 1

HCID 220291421-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

実験手順

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-(trifluoromethyl)aniline (3.85 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

後処理

  1. customas described in Preparation Example 37

出典と根拠

ORDレコード
ord-1420590f7cb24c4fb388c04d73723f4b
出典データセット
uspto-grants-2003_08
特許番号
US06605620B1

反応ノート

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