Bromine → 3-(2-Bromoacetyl)-4-hydroxybenzoic acid
反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[OH:13])[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[Br:14]Br>C(O)(=O)C>[Br:14][CH2:2][C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[OH:13])[C:7]([OH:9])=[O:8])=[O:3]参加物
4
反応条件
- 温度
- 80 °C
実験手順
The compound obtained in Step A (32.2 mmol) is dissolved in glacial acetic acid (40 ml) and then 48.3 mmol of bromine are added. The mixture is heated at 80° C. for 2 hours and is then hydrolysed using ice-cold water. The precipitate obtained is filtered off, washed with water until a pH of 5-6 is obtained, and then dried and recrystallised.
後処理
- customThe precipitate obtained
- filtrationis filtered off
- washwashed with water until a pH of 5-6
- customis obtained
- customdried
- customrecrystallised
出典と根拠
- ORDレコード
- ord-c386defd6d5e4fea945844a689b518b5
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06605632B1
反応ノート
読み込み中…