P-Anisidine → 2-amino-N-(4-methoxyphenyl)benzamide

HRID 395709

反応式

HRID 395709 の反応式
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH3:13])=[CH:16][CH:17]=1)=[O:4]

参加物

4

反応物 2

HCID 7732P-AnisidineHCID 8359Isatoic Anhydride

生成物 1

HCID 4788202-amino-N-(4-methoxyphenyl)benzamide収率 73%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of isatoic anhydride (4.9 g, 30 mmol) and p-anisidine (3.7 g, 30 mmol) in toluene (60 mL) was heated to reflux for 5 h. After cooling, the supernatant was decanted and the solid was suspended in methylene chloride (500 mL). The resulting suspension was filtered. The filtrate was combined with the supernatant from above, partially concentrated, diluted with hexane, and decolorized with charcoal. The resulting crystallization provided 5.3 g (73%) of the title compound as a white solid;

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 5 h
  3. temperatureAfter cooling
  4. customthe supernatant was decanted
  5. filtrationThe resulting suspension was filtered
  6. concentrationpartially concentrated
  7. additiondiluted with hexane
  8. customThe resulting crystallization

出典と根拠

ORDレコード
ord-787d9b95450744259c6fa6becaf718f2
出典データセット
uspto-grants-2003_08
特許番号
US06605626B2

関連ノート

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