Hydroxylamine, O-ethyl- → N-ethoxy-3-(4-iodo-phenylamino)-isonicotinamide

HRID 39573

反応式

HRID 39573 の反応式
Cl[C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH2:19]([O:21][NH2:22])[CH3:20]>>[CH2:19]([O:21][NH:22][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:2]=[CH:7][C:6]([I:8])=[CH:5][CH:4]=1)[CH3:20]

参加物

3

反応物 2

HCID 69357Hydroxylamine, O-ethyl-HCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2 回

生成物 1

HCID 86629194N-ethoxy-3-(4-iodo-phenylamino)-isonicotinamide

実験手順

N-ethoxy-3-(4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.30 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 0.40 mmol of O-ethyl-hydroxylamine LC/MS [9.14 min; 418 (M+1)]

出典と根拠

ORDレコード
ord-ed5c4960515f4ba3aac8276d85e804d8
出典データセット
uspto-grants-2013_09
特許番号
US08524911B2

関連ノート

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