Methanol → Methyl 2,2-dimethylpent-4-enoate

HRID 395897ノート

反応式

HRID 395897 の反応式
[CH3:1][C:2]([CH3:9])([CH2:6][CH:7]=[CH2:8])[C:3]([OH:5])=[O:4].[CH3:10]O.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[CH3:1][C:2]([CH3:9])([CH2:6][CH:7]=[CH2:8])[C:3]([O:5][CH3:10])=[O:4]

参加物

5

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1400652,2-Dimethyl-4-pentenoic acid

生成物 1

HCID 11768679Methyl 2,2-dimethylpent-4-enoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2,2-Dimethyl-4-pentenoic acid (15 g, 0.117 mol) was mixed with 70 mL anhydrous methanol and 50 mL toluene. Concentrated sulfuric acid (0.1 mL) was added. The solution was refluxed for 24 h. Solvents were then removed. The crude product was distilled under reduced pressure to gave 6 g pure product. 1H NMR(CDCl3) δ1.28(s, 6H, —CMe2—); 2.37(d, 2H, CH2═CHCH2—); 3.77(s, 3H, —CO2Me); 5.15(m, 2H, CH2═CH—); 5.84(m, 1H, CH2═CH—)

後処理

  1. temperatureThe solution was refluxed for 24 h
  2. customSolvents were then removed
  3. distillationThe crude product was distilled under reduced pressure

出典と根拠

ORDレコード
ord-b28d5c9c0660451397b170954272443c
出典データセット
uspto-grants-2003_08
特許番号
US06605679B1

反応ノート

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