化工社化工社 化学情報印刷レポート · 研究参考用
Imidazole → (S)-2-(tert-Butyldimethylsilyloxy)-g-butyrolactone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 反応物 | 3-Hydroxybutyrolactone, (3S)- | HCID 7269389 | — |
| 生成物 | (S)-2-(tert-Butyldimethylsilyloxy)-g-butyrolactone | HCID 10965951 | — |
反応手順
3.92 g (38.4 mmol) of (S)-3-hydroxybutyrolactone with 5.23 g (2 equivalents, 76.8 mmol) of imidazole are introduced at 0° C. into 50 ml of absolute DMF. 7.53 g (1.3 equivalents, 49.92 mmol) of TBSCl is now slowly added and stirred for 2.5 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06605726B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-6a09d1ba34d54481a03948cc134cebb3 |
| 出典メモ | uspto-grants-2003_08 |