関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Ethanone, 1-(4-octylphenyl)- | HCID 66344 | — |
| 反応物 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Bromo-1-(4-octylphenyl)ethanone | HCID 11301375 | — |
反応手順
To a solution of 4′-octylacetophenone (18′) (23.9 g) in acetic acid (100 ml) is added hydrogen bromide-acetic acid solution (25%, 34 ml) under ice-cooling, which is followed by dropwise addition of bromine (5.3 ml). The mixture is heated to 30° C. and stirred for 3 hr. The solvent is distilled away and the mixture is purified by silica gel column chromatography to give 2-bromo-4′-octylacetophenone as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06605744B2 |
|---|
| 出典データセット | uspto-grants-2003_08 |
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| ORD ID | ord-faea09a6a2f9430a80343b9ac5129c58 |
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| 出典メモ | uspto-grants-2003_08 |
|---|
