化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → Fmoc-leucine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(2-methylpropyl)- | HCID 11727923 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Fmoc-leucine | HCID 1549133 | — |
反応手順
FMOC-Leu*-Cl was prepared by dissolving FMOC-N-isobutylglycine (150 mg, 0.42 mmol) in CH2Cl2 (2.8 mL), and adding thionyl chloride (309 μL, 4.2 mmol) and 3 μL DMF (0.04 mmol). The reaction mixture was stirred for 5 hours and concentrated in vacuo, repeatedly dissolving in CH2Cl2 (3××) to provide FMOC-Leu*-Cl as a colorless oil (146 mg, 92%): IR (cm−1) −1804, 1720, 1715. FMOC-Phe*-Cl was similarly prepared.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06608026B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-6034ad8ef5ff4f3dae7ffeb683697265 |
| 出典メモ | uspto-grants-2003_08 |