Stannous chloride dihydrate → HCID 178441966、化合物

HRID 396132ノート

反応式

HRID 396132 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[C:9](=O)[CH2:10][CH:11]([CH3:13])[CH3:12].[N:15]([O-])=O.[Na+].O.O.[Sn](Cl)Cl>O.Cl>[OH:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[NH:1][N:15]=[C:9]2[CH2:10][CH:11]([CH3:13])[CH3:12]

参加物

6

反応物 3

HCID 61436Stannous chloride dihydrateHCID 230030541-(2-Amino-5-hydroxyphenyl)-3-methyl-1-butanoneHCID 23668193Sodium Nitrite

生成物 1

HCID 178441966HCID 178441966、化合物収率 41.1%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒2 回HCID 962Water溶媒

実験手順

In an analogous manner to the procedure of Example XIV, 783 mg (4.05 mmol) of 1-(2-amino-5-hydroxyphenyl)-3-methyl-1-butanone in 30 ml of half-conc. hydrochloric acid are reacted with 294 mg (4.25 mmol) of sodium nitrite in 15 ml of water and 914 mg (4.05 mmol) of tin(II) chloride dihydrate in 15 ml of conc. hydrochloric acid to give 317 mg (41%) of 5-hydroxy-3-isobutyl-1H-indazole.

出典と根拠

ORDレコード
ord-ac4c4b51e7d34aea93cc5e2f5f6ecc78
出典データセット
uspto-grants-2003_08
特許番号
US06608049B2

反応ノート

読み込み中…