関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-(2-Aminoethylamino)-5-nitropyridine | HCID 122425 | — |
| 反応物 | 3-(2,4-Dichlorophenyl)-5-bromo-2-nitropyrazine | HCID 22318510 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [6-(2,4-Dichlorophenyl)-5-nitropyrazin-2-yl]{2-[(4-nitrophenyl)amino]ethyl}amine | HCID 22318509 | — |
反応手順
To a solution of 3-(2,4-dichlorophenyl)-5-bromo-2-nitropyrazine (20 mg, 0.057 mmol) in DMF (1 ml), (2-aminoethyl)(5-nitro(2-pyridyl))amine (11.3 mg, 0.06 mmol) and diisopropylethyl amine (40 μl, 0.228 mmol) were added. The reaction mixture was stirred for 12 hours at 80° C. The crude mixture was concentrated in vacuo and subjected to column chromatography (5% methanol in methylene chloride) to afford the title compound as bright yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06608063B2 |
|---|
| 出典データセット | uspto-grants-2003_08 |
|---|
| ORD ID | ord-5c654bb31bcd454bbdaa76792d4ffac4 |
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| 出典メモ | uspto-grants-2003_08 |
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