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(1S)-1-phenylpropan-1-amine → (S)-N-(alpha-Ethylbenzyl)-3-methyl-7-methoxy-2-phenylquinoline-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1S)-1-phenylpropan-1-amine | HCID 6993773 | — |
| 反応物 | 3-Methyl-7-methoxy-2-phenylquinoline-4-carbonylchloride | HCID 22714324 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-N-(alpha-Ethylbenzyl)-3-methyl-7-methoxy-2-phenylquinoline-4-carboxamide | HCID 53800998 | — |
反応手順
Prepared as described in Ex. 1, starting from 1.27 g ( 4.09 mmol) of crude 3-methyl-7-methoxy-2-phenylquinoline-4-carbonylchloride, 0.55 g (4.09 mmol) of (S)-(−)-a-ethylbenzylamine and 1.71 ml (12.27 mmol) of TEA in 24 ml of dry CH2Cl2 and 1 ml of DMF to help solubility. The reaction mixture was stirred 12 hours at room temperture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06608083B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-a7c8de74fa7b4a0d849fbb2e816c55a4 |
| 出典メモ | uspto-grants-2003_08 |