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Propargyl bromide → 7-Propynyloxyflavone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propargyl bromide | HCID 7842 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 7-Hydroxyflavone | HCID 5281894 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 7-Propynyloxyflavone | HCID 18171843 | — |
反応手順
A mixture of 7-hydroxyflavone (2.38 g, 0.01 mol), K2CO3 (2.8 g, 0.02 mol), Kl (0.166 g, 0.001 mol), propargyl bromide (1.78 g, 0.015 mol) and acetone (100 mL) was refluxed 10 h and hot filtered. The solvent was evaporated and the residue was crystallized by toluene. This yields 2.58 g of a product with the following characteristics: m.p. 199-200° C.; 1H NMR (CDC13) δ: 2.6 (m, 1H), 4.8 (s, 2H), 6.75-8.18 (m, 9H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06608089B2 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-bd3a5c6268414d7c95b108d5ce7466a1 |
| 出典メモ | uspto-grants-2003_08 |