Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate → Methyl[5-chloro-2-(thiazole-2-carbonyl)-1h-indol-3-yl]acetate
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14]S(C2C=CC=CC=2)(=O)=O)=[C:6]([CH:13]=1)/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10].Br.Br[CH2:26][C:27]([C:29]1[S:30][CH:31]=[CH:32][N:33]=1)=[O:28]>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:13]=2)[NH:14][C:26]=1[C:27]([C:29]1[S:30][CH:31]=[CH:32][N:33]=1)=[O:28]参加物
3
実験手順
The title compound was prepared according to the procedure described in step 2 of Example 8 (Method A) from methyl trans-5-chloro-2-(phenylsulfonylamino)cinnamate (Example 36, step 3) and 2-bromoacetylthiazole hydrobromide (A. Dondoni, A. Marra, and P. Merino, J. Am. Chem. Soc., 1994, 116, 3324).
出典と根拠
- ORDレコード
- ord-e414640a30c04e6489dbe4e7ce09d6b9
- 出典データセット
- uspto-grants-2003_08