3,5-Dimethylpyridine-2-carbonitrile → 1-(3,5-Dimethylpyridin-2-YL)ethanone

反応式

CC1C(C#N)=NC=C(C)C=1.C(C1C=C(Cl)C=CN=1)(=O)C.Br.Br[CH2:23][C:24]([C:26]1[C:31]([CH3:32])=[CH:30][C:29]([CH3:33])=[CH:28][N:27]=1)=[O:25]>>[C:24]([C:26]1[C:31]([CH3:32])=[CH:30][C:29]([CH3:33])=[CH:28][N:27]=1)(=[O:25])[CH3:23]

参加物

反応物 3

HCID 81672693,5-Dimethylpyridine-2-carbonitrile

HCID 130119861-(4-Chloro-pyridin-2-yl)-ethanone

HCID 23003480HCID 23003480、化合物

生成物 1

HCID 230034111-(3,5-Dimethylpyridin-2-YL)ethanone

実験手順

The title compound was prepared from 3,5-dimethylpyridinecarbonitrile (K. Takahashi et al., J. Heterocycl. Chem., 1978, 15, 893) according to the procedure for preparing 2-acetyl-4-chloropyridine described in Example 33. 1H-NMR (CDCl3) δ: 8.32 (1H, s), 7.37 (1H, s), 2.69 (3H, s), 2.56 (3H, s), 2.36 (3H, s). 2-Bromoacetyl-3,5-dimethylpyridine hydrobromide:

出典と根拠

ORDレコード: ord-daded8e4a70c45fe81c44b5c5c71b4ad
出典データセット: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06608070B1

反応ノート

読み込み中…

参加物