Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate → Methyl[5-chloro-2-(thiazole-5-carbonyl)-1h-indol-3-yl]acetate

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14]S(C2C=CC=CC=2)(=O)=O)=[C:6]([CH:13]=1)/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10].Br.Br[CH2:26][C:27]([C:29]1[S:33][CH:32]=[N:31][CH:30]=1)=[O:28]>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:13]=2)[NH:14][C:26]=1[C:27]([C:29]1[S:33][CH:32]=[N:31][CH:30]=1)=[O:28]

参加物

反応物 2

HCID 11187263Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate

HCID 230035582-Bromo-1-(thiazol-5-yl)ethanone hydrobromide

生成物 1

HCID 23003501Methyl[5-chloro-2-(thiazole-5-carbonyl)-1h-indol-3-yl]acetate

実験手順

The title compound was prepared according to the procedure described in Example 57 from methyl trans-5-chloro-2-(phenylsulfonylamino)cinnamate (Example 36, step 3) and 5-bromoacetylthiazole hydrobromide*.

出典と根拠

ORDレコード: ord-933728d1be43424095a1fd9f9c8d3d05
出典データセット: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06608070B1

反応ノート

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