Water → 4-(2-Furyl)Aniline Hydrochloride

HRID 396753ノート

反応式

HRID 396753 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.O>C(O)C>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 962WaterHCID 6049692-(4-Nitrophenyl)furan

生成物 1

HCID 41911054-(2-Furyl)Aniline Hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

To a suspension of 2-(4-nitrophenyl)furan (0.378 g, 2 mmol, prepared according to the method of Heterocycles, 1990, 31, 1951) in ethanol (20 mL) was heated to 70° C. and added stannous chloride dihydrate (2.26 g, 10 mmol) and the mixture was stirred for 2 hours. The reaction mixture was cooled to room temperature and poured into water (50 mL), the whole was extracted with ethyl acetate (30 mL×2). The organic layer was dried over Na2SO4, filtered through celite and concentrated to give the crude subtitle compound (0.35 g).

後処理

  1. customprepared
  2. temperatureThe reaction mixture was cooled to room temperature
  3. extractionthe whole was extracted with ethyl acetate (30 mL×2)
  4. dry with materialThe organic layer was dried over Na2SO4
  5. filtrationfiltered through celite and
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-647ab23400524ea8824f626b1ac31a5a
出典データセット
uspto-grants-2003_08
特許番号
US06608095B2

反応ノート

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