Sulfuric Acid → Phenol, 3-bromo-, 1-acetate

HRID 396789ノート

反応式

HRID 396789 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.C([O-])(O)=O.[Na+].[C:19](OC(=O)C)(=[O:21])[CH3:20]>O>[C:19]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)(=[O:21])[CH3:20]

参加物

6

反応物 4

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 115633-BromophenolHCID 516892Sodium Bicarbonate

生成物 1

HCID 141946Phenol, 3-bromo-, 1-acetate収率 99%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred solution of 3-bromophenol (25 g, 145 mmol) in acetic anhydride (14 ml) was added a few drop of sulfuric acid, and the mixture was stirred for 2 hours. The mixture was poured into a solution of NaHCO3 (1.3 g, 15.5 mmol) in water (160 ml). The whole was extracted with diethylether. The organic layer was washed with saturated NaHCO3 aqueous solution, brine, dried over MgSO4, and concentrated in vacuo. The residue was used for next reaction without purification. (31 g, 99% yield).

後処理

  1. extractionThe whole was extracted with diethylether
  2. washThe organic layer was washed with saturated NaHCO3 aqueous solution, brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was used for next reaction without purification

出典と根拠

ORDレコード
ord-d03daa0cdf5640529f69289a7f618800
出典データセット
uspto-grants-2003_08
特許番号
US06608095B2

反応ノート

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