化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Sulfite → 3-Hydroxymethyl-4-(methylsulfonyl)nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | 3-Hydroxymethyl-4-(methylthio)nitrobenzene | HCID 22316807 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Hydroxymethyl-4-(methylsulfonyl)nitrobenzene | HCID 22316955 | 67.5% |
反応手順
To a solution of 3-hydroxymethyl-4-(methylthio)nitrobenzene from step 1 (20 g, 0.10 mol) in CH2Cl2 (500 mL) and MeOH (100 mL), m-CPBA (74 g, 0.30 mol) was added portionwise at 0° C., and the mixture was stirrred for 16 h at room temperature. The mixture was added aqueous Na2SO3 (20 g in 200 mL of water) at 0° C. Organic layer was separated and washed with saturated aqueous NaHCO3 (300 mL), dried over MgSO4, and concentarted in vacuo gave the title compound (15.6 g, 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06608095B2 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-140c39121b1f478c9525ee309be3571e |
| 出典メモ | uspto-grants-2003_08 |