Cesium carbonate → 1-(1,3-Dioxolan-2-ylmethyl)-7-methylquinolin-2(1h)-one

HRID 39686

反応式

HRID 39686 の反応式
Br[CH2:2][CH:3]1[O:7][CH2:6][CH2:5][O:4]1.[CH3:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15](=[O:19])[NH:16]2)=[CH:11][CH:10]=1.C(=O)([O-])[O-].[Cs+].[Cs+].C(=O)([O-])O.[Na+]>O.C(OCC)(=O)C.CS(C)=O>[O:4]1[CH2:5][CH2:6][O:7][CH:3]1[CH2:2][N:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([CH3:8])[CH:18]=2)[CH:13]=[CH:14][C:15]1=[O:19]

参加物

8

反応物 4

HCID 10796Cesium carbonateHCID 776737-Methyl-2-quinoloneHCID 780681,3-Dioxolane, 2-(bromomethyl)-HCID 516892Sodium Bicarbonate

生成物 1

HCID 593978351-(1,3-Dioxolan-2-ylmethyl)-7-methylquinolin-2(1h)-one

試薬・触媒・溶媒 3

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
65 °C

実験手順

To 6.3 mL of a dimethyl sulfoxide solution containing 1.1 g of 2-bromomethyl-1,3-dioxolane, 1.0 g of 7-methylquinolin-2(1H)-one and 3.1 g of cesium carbonate were added, and the mixture was stirred at 60 to 70° C. for 1 hour. The reaction mixture was added with ethyl acetate, water and an aqueous saturated sodium hydrogen carbonate solution. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with water and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=2:3] to obtain 0.60 g of a brown oily substance, 1-(1,3-dioxolan-2-ylmethyl)-7-methylquinolin-2(1H)-one.

後処理

  1. additionwere added
  2. customThe organic layer was separated
  3. extractionthe aqueous layer was extracted with ethyl acetate
  4. washthe resultant solution was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was removed under reduced pressure
  7. customThe residue thus obtained
  8. customwas purified by silica gel column chromatography [eluent; hexane:ethyl acetate=2:3]

出典と根拠

ORDレコード
ord-9041a22baa42428fbde1e34aa3e447f7
出典データセット
uspto-grants-2013_09
特許番号
US08524738B2

関連ノート

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