化工社化工社 化学情報印刷レポート · 研究参考用
Boc-N-Me-Phe-OH → (2S)-6-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]-3-phenyl-propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boc-N-Me-Phe-OH | HCID 7010602 | — |
| 反応物 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine | HCID 23552860 | — |
| 生成物 | (2S)-6-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]-3-phenyl-propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508602 | — |
反応手順
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using commercially available Nα-tert-butoxycarbonyl-Nα-methyl-L-phenylalanine (83 mg, 0.3 mmol). The final product was triturated with ether to yield 176 mg (90%) of the desired material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06608100B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-8c72e1815079491b8b6dbabae9163ec8 |
| 出典メモ | uspto-grants-2003_08 |