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3-Aminopyridine → (2S)-2-[isobutyl(p-tolylsulfonyl)amino]-6-[[2-(3-pyridylamino)acetyl]amino]hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopyridine | HCID 10009 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-Nepsilon-iodoacetyl-L-lysine | HCID 86589941 | — |
| 生成物 | (2S)-2-[isobutyl(p-tolylsulfonyl)amino]-6-[[2-(3-pyridylamino)acetyl]amino]hexanoic acid | HCID 508627 | — |
反応手順
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-Nε-iodoacetyl-L-lysine (200 mg, 0.38 mmol, example 105, step B) by following the indications of general procedure H using DIEA (0.19 mL, 1.09 mmol) and 3-aminopyridine (175 mg, 1.36 mmol). The crude material was purified by preparative HPLC. The product was isolated as a solid (42 mg, 22% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06608100B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-8d41696b5a64439b8cf914556d49ae93 |
| 出典メモ | uspto-grants-2003_08 |